Anticancer agents from Solanum Surattense

Authors

  • Mahreen Mukhtar
  • Saima Khan
  • Naheed Riaz
  • Muhammad Imran Tousif
  • Mamona Nazir
  • Abdul Jabbar
  • Muhammad Saleem

DOI:

https://doi.org/10.52700/fcs.v1i1.4

Keywords:

anticancer activity, steroids glycosides, anticancer 3T3 cell line, Solanum surattense, structure elucidation

Abstract

Two steroids glycosides solamargine (1) and dioscine (2) were isolated from methanolic extract of Solanum surattense and evaluated for their anticancer activity. The structure of the isolated compounds was identified through 1D and 2D NMR techniques, mass spectrometry and in comparison, with the literature values of their spectroscopic data. Both compounds showed the excellent anticancer activity against NIH-3T3 fibroblast cancer cell line with IC50 value of 7.55±1.5 and 3.3±1.9µg/ml respectively which were comparable with control Cyclohexamide which showed the IC50 value of 0.8± 0.2 µg/ml.

Published

2020-06-30

How to Cite

Mukhtar, M., Khan, S., Riaz, N., Tousif, M. I., Nazir, M., Jabbar, A., & Saleem, M. (2020). Anticancer agents from Solanum Surattense . FRONTIERS IN CHEMICAL SCIENCES, 1(1), 15-20. https://doi.org/10.52700/fcs.v1i1.4

Issue

Vol. 1 No. 1 (2020): Frontiers in Chemical Sciences

Section

Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.