A Synthesis and Pharmaceutical Evaluation of Pyrimidine Derivatives and Their Docking Studies
Keywords:Pyrimidine derivatives, MTT assays, grindstone, human HepG2 Liver cell Lines, NMR analysis, Mass spectroscopy
A series of halogenated pyrimidine derivatives tetrahydropyrimidine; Ethyl-6-methyl2-oxo-4-phenyl-1,3,4-tetrahydropyrimidine-5-carboxylate (10a), Ethyl-4-(3-
Chlorophenyl)-6-methyl-2-oxo-1,3,4-tetrahydropyrimidine-5- carboxylate (10b) and
carboxylate (10c) were synthesized by using new strategy in “Grindstone protocol “to
get high yield in short time. The synthesized compounds werecharacterized by 1HNMR, 13C-NMR and Mass spectral data and evaluated for their anticancer
activityagainsthuman HepG2 Liver cell lines, for antifungal and insecticidal activities.
All the synthesized compounds (10a-c) were studied to measure the interactions by
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