A Synthesis and Pharmaceutical Evaluation of Pyrimidine Derivatives and Their Docking Studies

Authors

  • Nusrat Shafiq
  • Azhar Rasul
  • Sonia Ashraf
  • Shagufta Parveen
  • Sania Zafar Iqbal
  • Ki Hyun Kim
  • Rashid Khan
  • Basharat Ali
  • Farhat Jabeen
  • Sadia Naureen

DOI:

https://doi.org/10.52700/fcs.v1i2.9

Keywords:

Pyrimidine derivatives, MTT assays, grindstone, human HepG2 Liver cell Lines, NMR analysis, Mass spectroscopy

Abstract

A series of halogenated pyrimidine derivatives tetrahydropyrimidine; Ethyl-6-methyl2-oxo-4-phenyl-1,3,4-tetrahydropyrimidine-5-carboxylate (10a), Ethyl-4-(3-
Chlorophenyl)-6-methyl-2-oxo-1,3,4-tetrahydropyrimidine-5- carboxylate (10b) and
Ethyl-4-(4-Chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-
carboxylate (10c) were synthesized by using new strategy in “Grindstone protocol “to
get high yield in short time. The synthesized compounds werecharacterized by 1HNMR, 13C-NMR and Mass spectral data and evaluated for their anticancer
activityagainsthuman HepG2 Liver cell lines, for antifungal and insecticidal activities.
All the synthesized compounds (10a-c) were studied to measure the interactions by
docking study.

Published

2020-12-31

How to Cite

Shafiq, N. ., Rasul, A. ., Ashraf, S., Parveen, S. ., Zafar Iqbal, S., Kim, K. H. ., Khan, R., Ali, B. ., Jabeen, F., & Naureen, S. (2020). A Synthesis and Pharmaceutical Evaluation of Pyrimidine Derivatives and Their Docking Studies. FRONTIERS IN CHEMICAL SCIENCES, 1(2), 19-28. https://doi.org/10.52700/fcs.v1i2.9

Issue

Vol. 1 No. 2 (2020): Frontiers in Chemical Sciences

Section

Articles
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