Thiazolidines; The Potential Antimicrobial Agents Against Methicillin-Resistant Strains of Staphylococcus aureus

Authors

  • Mehwish Tanveer
  • Hira Musaddiq
  • Atia Iqbal
  • Sarwat Saleem
  • Sadia Iqbal
  • Basharat Ali
  • Kiran Mustafa
  • Sara Musaddiq

DOI:

https://doi.org/10.52700/fcs.v1i1.3

Keywords:

Antimicrobial, L-cystiene, Bacterial strains, MRSA

Abstract

2-Substituted 1,3-Thiazolidine-4-Carboxylic Acids (1-11) were synthesized and screened for their anti-methicillin-resistant Staphylococcus aureus (MRSA) potential. The synthesized compounds were evaluated for their antibacterial activities against four MRSA strains MRSA I, VI, VII and VIII with accession numbers KU662352, KR862285, KR862291 and KU662354 respectively by well diffusion method. In addition, antibacterial evaluations were also performed for gram positive strain Bacillus subtilis and gram-negative strains klebsiella pneumoniae and pseudomonas aeruginosa using same method. Most of the synthesized thiazolidine-4-carboxylic acid derivatives exhibited better antibacterial activities against studied bacterial strains. Amongst the synthesized compounds, 8-10 were found to possess significant activity (Zone in mm) against methicillin-resistant Staphylococcus aureus in addition to the other studied bacterial strains.

Published

2020-06-30

How to Cite

Tanveer, M. ., Musaddiq, H. ., Iqbal, A. ., Saleem, S. ., Iqbal, S. ., Ali, B. ., Mustafa, K. ., & Musaddiq, S. . (2020). Thiazolidines; The Potential Antimicrobial Agents Against Methicillin-Resistant Strains of Staphylococcus aureus. FRONTIERS IN CHEMICAL SCIENCES, 1(1), 9-14. https://doi.org/10.52700/fcs.v1i1.3