Synthesis, Characterization, Antioxidant and Biological Activities of Polyglucose Based Hydrazides and their Metal Nano Composites
Keywords:Hydrazides, Polyglucose, Biological activities, Metal nanocomposites, EDXS.
The interaction of carbon (C) and nitrogen (N) single, double, and triple bonds with an aliphatic and aromatic carbon skeleton is widely used for medications and polymer synthesis. Many scientists have employed these compounds as target structures to determine their diverse chemical synthesis and use in various fields. The synthesis of polyglucose-hydrazide metal nanocomposites is a novel area of chemistry research. Polyglucose metal nanocomposites are widely used for drug delivery to target cancer and other lethal diseases. The major interests of this research were to synthesize, characterize, and find out the antibacterial properties of hydroxyl groups present in polyglucose-hydrazide metal nanocomposites. These nanocomposites were synthesized by acidification, esterification, and hydrazination of glucose and mixing of metal nanoparticles with polyglucose, respectively. The characterization of proposed nanocomposites was done by using scanning electron microscopy (SEM) and, energy dispersive X-Ray (EDX) spectroscopy. The biological activities of polyglucose-hydrazides cobalt, silver, and iron nano-composites were tested against Xanthomonas campestris malvacearum (a bacterial strain) by agar disc diffusion method. Amongst all, polyglucose-hydrazides cobalt nanocomposite yielded the highest antibacterial activity. Silver and iron nanocomposites also showed good activity. These results indicate that the antibacterial activities of metal nanoparticles are remarkably enhanced by combining with polyglucose hydrazide. These polyglucose-hydrazide metal nanocomposites have great potential as biocompatible antibacterial agents.
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